منابع مشابه
APOBEC3 Interference during Replication of Viral Genomes
Co-evolution of viruses and their hosts has reached a fragile and dynamic equilibrium that allows viral persistence, replication and transmission. In response, infected hosts have developed strategies of defense that counteract the deleterious effects of viral infections. In particular, single-strand DNA editing by Apolipoprotein B Editing Catalytic subunits proteins 3 (APOBEC3s) is a well-cons...
متن کاملDirected DNA deamination by AID/APOBEC3 in immunity
Several hundred papers in the past seven years have established two new mechanisms of immunity, both of which are dependent upon proteins that deaminate cytosines to uracils within singlestranded DNA. Activation-induced deaminase (AID) deaminates C -> U to implement the diversification of vertebrate antibody genes and mammalian APOBEC3 proteins, such as human APOBEC3F and APOBEC3G, deaminate C ...
متن کاملMassive APOBEC3 Editing of Hepatitis B Viral DNA in Cirrhosis
DNA viruses, retroviruses and hepadnaviruses, such as hepatitis B virus (HBV), are vulnerable to genetic editing of single stranded DNA by host cell APOBEC3 (A3) cytidine deaminases. At least three A3 genes are up regulated by interferon-alpha in human hepatocytes while ectopic expression of activation induced deaminase (AICDA), an A3 paralog, has been noted in a variety of chronic inflammatory...
متن کاملAPOBEC3 proteins inhibit human LINE-1 retrotransposition.
The human cytidine deaminase family APOBEC3 represents a novel group of proteins in the field of innate defense mechanisms that has been shown to be active against a variety of retroviruses. Here we examined whether members of the APO-BEC3 family have an impact on retrotransposition of human long interspersed nuclear elements (LINE-1s or L1s). Using a retrotransposition reporter assay in HeLa c...
متن کاملAPOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans
Since the identification of APOBEC3G (A3G) as a potent restriction factor of HIV-1, a tremendous amount of effort has led to a broadened understanding of both A3G and the APOBEC3 (A3) family to which it belongs. In spite of the fine-tuned viral counterattack to A3 activity, in the form of the HIV-1 Vif protein, enthusiasm for leveraging the Vif : A3G axis as a point of clinical intervention rem...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2015
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1501504